References
Nayak, D.
P., Hui, E. K., & Barman, S. (2004). Assembly and budding of influenza
virus. Virus Research, 106(2), 147-165.
doi:10.1016/j.virusres.2004.08.012
This review mainly discusses the biological
process of assembly and budding of influenza virus by emphasizing the role that
M1 protein plays in the entire virus-host system. Viral particle of influenza
is composed of viral envelope, matrix and core (viral ribonucleocapsid vRNP). M1
protein is considered as a bridge between viral core and envelope. During
assembly process, M1 is generated at cytosolic ribosomes, and then directed to
facilitate vRNP exportation from nucleus to cytoplasm, with the companion of
NEP. At this stage, interaction of M1 with cytoplasmic tail and transmembrane
domain is critical for the concentration of viral composition at budding site.
Also, M1 is thought to be important in budding of the virus by presenting L
motif (what is that?).
The author addressed most of major activity in
virus replication, while there are some problems that need further examination.
The mechanism of the translocation of M1 and vRNP, from nuclear to plasma
membrane (assembly site) is still unsolved. Besides viral components like M1
protein, there are a variety of host factors involved in viral budding and most
of them are under discovery.
(3D structure of M1 protein, from NCBI)
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