Wednesday, October 24, 2012

Somatic Recombination

It is generally known that during the phrase of B cell maturation, various antibodies are generated for specific antigens. You might want to ask how the cells utilizes its biological function, to produce 10x15 different types of antibody encoded by only 10x5 genes. The current consensus is that antibody is produced by somatic recombination (aka VDJ recombination) before it is secreted by plasma cells. Immunoglobulin genes are results of recombination of different DNA fragments, gaining their diversity and specificity. This process happened in every B cells which undergo maturation from naive B cells. (Instant Notes in Biochem)

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