There has been
previously a classic perception regarding the genetic segregation of influenza
viruses all over the world: the virus has been divided into west hemisphere
clade and east hemisphere clade, or to say, North American lineage and Eurasian
lineage, as a result of long-term geographical and ecological separation of
migrating wild birds. We all know that the global transmission of avian
influenza is due to its natural reservoir, multiple kinds of wild birds. The
viruses alway cause asymptomatic infection in wild birds, who carry them to
travel the world. However, because of the climatic change and geographical
distance, the birds cannot "make it" through the gigantic pacific
ocean. The gene pool of influenza viruses, therefore, is categorized into lineages.
Just take a look at M segments of H8N4, it obviously indicates that the gene is
actually different between the viruses that identified in North America or
Eurasian continent.
It is rare to find
virus circulation across the hemisphere, but this separation is not alway the
case. There exists some well-established flyways of wild duck that are in the
overlapping region across hemisphere. For example, the east Atlantic flyway
seems to be a promising way to lead to virus transmission across the bound. Some
researchers even proved the evasion of Eurasian clade towards North American
clade by phylogenetic analysis. HPAI H5N1 is originated from Asia, without any
evidence founded in North America. Either to evade or to take over right away
by seasonal migrating pathway, all that HPAI needs is just time.
(well I would say it is quite fascinating to see the migrating viruses)
(well I would say it is quite fascinating to see the migrating viruses)
References
Global Patterns of
Influenza A Virus in Wild Birds
•
Björn Olsen, Vincent J. Munster, Anders
Wallensten, Jonas Waldenström, Albert D. M. E. Osterhaus,and Ron
A. M. Fouchier
Science 21 April 2006: 312 (5772), 384-388. [DOI:10.1126/science.1122438]
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